Benign Recurrent Intrahepatic Cholestasis (BRIC) and Progressive Familial Intrahepatic Cholestasis (PFIC)
BRIC and PFIC are part of the same spectrum of rare liver diseases that affect bile flow in the liver. While they are related, their course and presentation can differ significantly from person to person.
What is PFIC?
Progressive Familial Intrahepatic Cholestasis (PFIC) is a group of rare genetic liver disorders that typically begin in infancy or early childhood. PFIC disrupts the normal flow of bile out of the liver, leading to a buildup that causes symptoms such as severe itching (pruritus), jaundice, poor growth, and potentially liver failure over time. PFIC tends to follow a more continuous and progressive course, often requiring long-term management or liver transplantation.
What is BRIC?
Benign Recurrent Intrahepatic Cholestasis (BRIC) is considered a milder, more intermittent form within the PFIC spectrum. People with BRIC experience episodes—or “attacks”—of symptoms such as jaundice and itching, followed by periods of normal health. These episodes can vary in length and frequency. Although BRIC is often less severe, in rare cases, it can become more frequent or evolve into a disease course more similar to PFIC.
Because of this overlap, BRIC is now recognized as part of the broader PFIC disease spectrum.
Support and Resources for BRIC and PFIC Families
Families affected by BRIC are fully welcomed into the PFIC Network community and have access to the same resources and services as those with PFIC. We are committed to supporting everyone across this disease spectrum.
Support Group: BRIC, PFIC and Other Rare Liver Diseases
BRIC, PFIC and other rare liver diseases-This private Facebook group is the largest online community for individuals and families affected by PFIC and BRIC. It is independently run, but members of the PFIC Network—including staff and board members who are also PFIC parents—are active in the group. It’s a great place to ask questions, share experiences, and find connection and community.
Patient Registry
Our patient registry is open to all individuals diagnosed with PFIC, BRIC, or other related cholestatic liver conditions. By joining the registry, you contribute valuable insights that can help advance research and improve care across the spectrum of these rare diseases.
Educational Materials
We provide a comprehensive Welcome Packet for newly diagnosed families, including:
- Disease education brochures
- Letters from PFIC Network leadership and families
- An introduction to our support services and advocacy work
This packet can help guide you through the early stages of diagnosis and help you feel more informed and connected.
Webinar Library
Our on-demand video library includes expert presentations from past conferences, covering:
- Genetics and the underlying biology of PFIC/BRIC
- Managing itching and other common symptoms
- Psychosocial support for patients and caregivers
These are available for free and can be accessed at any time. Through this link:Webinar Library
Financial Assistance Program
We understand that rare diseases can place financial strain on families. Our Financial Assistance Program offers support for medical travel, genetic testing, and other critical needs, depending on availability and eligibility.
Get Involved
Whether you’re newly diagnosed or further along in your journey, there’s a place for you in the PFIC Network. We are here to ensure that no one faces these challenges alone.
For more information visit our website at
Rare Disease Groups & Organisations
